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Acebutolol

Also indexed as: Sectral

Illustration

Acebutolol is used to treat high blood pressure and certain forms of heart arrhythmia, and is in a family of drugs known as beta-adrenergic blockers.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Avoid Avoid: Reduced drug absorption/bioavailability—Avoid these supplements when taking this medication since the supplement may decrease the absorption and/or activity of the medication in the body.

Food

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

High-potassium foods*

Pleurisy root*

Potassium supplements*

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

Potassium
Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the uptake of potassium from the blood into the cells,1 leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia.2 People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of fruit (for example, bananas), unless directed to do so by their doctor.

Interactions with Herbs

Pleurisy root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.3

Interaction with Foods and Other Compounds

Food
Taking acebutolol with food slows the rate of absorption and reduces the maximum blood levels of the drug, though overall absorption is not affected.4 However, the blood level of an active breakdown product of acebutolol is reduced.5 Though the activity of acebutolol is affected by food, people taking the drug on a daily basis are not likely to experience a reduction in the effectiveness of the drug if it is taken with a meal.

Grapefruit juice
In a study of healthy volunteers, drinking 200 ml of grapefruit juice at the same time as taking acebutolol caused a small decrease in blood levels of the drug by interfering with its absorption.6 Although the researchers who performed this study felt that the effect was unlikely to be clinically significant in most cases, it would seem prudent not to take grapefruit juice at the same time as acebutolol.

References:

1. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980;302:431–4.

2. Lundborg P. The effect of adrenergic blockade on potassium concentrations in different conditions. Acta Med Scand Suppl 1983;672:121–6 [review].

3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.

4. Sifton DW, ed. Physicians Desk Reference. Montvale. NJ: Medical Economics Company, Inc., 2000, 3317–9.

5. Zaman R, Wilkins MR, Kendall MJ, Jack DB. The effect of food and alcohol on the pharmacokinetics of acebutolol and its metabolite, diacetolol. Biopharm Drug Dispos 1984;5:91–5.

6. Lilja JJ, Raaska K, Neuvonen PJ. Effects of grapefruit juice on the pharmacokinetics of acebutolol. Br J Clin Pharmacol 2005;60:659–63.

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