Also indexed as: Lioresal
Baclofen is used to treat muscle spasms associated with multiple sclerosis and spinal cord injury, and it may
help with face pain due to trigeminal neuralgia. It is in a class of drugs known as centrally
acting skeletal muscle relaxants.
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
|Depletion or interference
|Side effect reduction/prevention
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions with Foods and Other Compounds
Baclofen absorption is not affected by food, but the drug should be taken with a meal to
minimize stomach upset.1
Drinking alcohol may enhance the side effects of baclofen, such as drowsiness, dizziness,
weakness, and fatigue.2 Therefore, people taking baclofen should avoid alcoholic
beverages, especially if staying alert is necessary.
1. Peterson GM, McLean S, Millingen KS. Food does not affect the
bioavailability of baclofen. Med J Aust 1985;142:689–90.
2. Olin BR, ed. Central Nervous System Drugs, Muscle Relaxants, Centrally
Acting. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and
Comparisons, 1993, 1529–30.