Also indexed as: Aluratec, Amobarbital, Amylbarbitone, Amytal,
Aprobarbital, Brevital, Busodium, Butabarbital, Butisol, Mebaral, Mephobarbital, Metharbital,
Methohexital, Nembutal, Pentobarbital, Pentothal, Pentothal, Phenobarbitone, Quinalbarbitone,
Secobarbital, Seconal, Sodium Pentothal, Talbutal, Thiamylal, Thiopental
Barbiturates are a family of drugs that depress nerve activity in the brain, which produces
changes in mental activity ranging from mild sedation and sleep, to deep coma. They are used
to treat anxiety, insomnia, seizure disorders, and migraine headaches. In addition, some barbiturates are
used in surgery as general anesthetics.
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results.
|Depletion or interference
|Side effect reduction/prevention
|Interactions common to many, if not all,
Barbiturates are described in this article. Interactions reported for only one or several
drugs in this class may not be listed in this article. Some drugs listed in this article are
linked to articles specific to that respective drug; please refer to those individual drug
articles. The information in this article may not necessarily apply to drugs in this class for
which no separate article exists. If you are taking a Barbiturate for which no separate
article exists, talk with your doctor or pharmacist.
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions involving barbiturates in general are described on this page. For interactions
involving a specific barbiturate, refer to the highlighted drugs listed below.
- Amobarbital (Amytal®)
- Aprobarbital (Alurate®)
- Butabarbital (Butisol®)
- Butalbital (Fiorinal®,
- Mephobarbital (Mebaral®)
- Methohexital (Brevital®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Thiopental (Pentothal®)
Interactions with Foods and Other Compounds
Drinking alcoholic beverages while taking barbiturates increases side effects, such as
drowsiness, confusion, and dizziness;1 if taken in excess, this combination may
result in death. Consequently, people taking barbiturates should avoid drinking alcohol.
1. Olin BR, ed. Central Nervous System Drugs, Sedatives and Hypnotics,
Barbiturates. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and
Comparisons, 1993, 1398–413.