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Chlorpheniramine

Also indexed as: Aller-Chlor, Chlor-Trimeton Allergy, Teldrin

Illustration

Chlorpheniramine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms including sneezing, runny nose, itching, and watery eyes. It is also used to treat immediate allergic reactions. Chlorpheniramine is available in nonprescription products alone and in combination with other nonprescription drugs, to treat symptoms of allergy, colds, and upper respiratory infections.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Henbane*

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

Henbane (Hyoscyamus niger)
Antihistamines, including chlorpheniramine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic activity and side effects. Therefore, use of henbane with chlorpheniramine could increase the risk of anticholinergic side effects,1 though apparently no interactions have yet been reported. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.

Interactions with Foods and Other Compounds

Alcohol
Chlorpheniramine causes drowsiness.2 Alcohol may intensify this effect and increase the risk of accidental injury.3 To prevent problems, people taking chlorpheniramine or chlorpheniramine-containing products should avoid alcohol.

References:

1. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council, 1998, 146.

2. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192.

3. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192.

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