Also indexed as: Anaspaz, Colidrops Liquid Pediatric,
Cystospaz, Donnamar, ED-Spaz, Hyco Elixir, Hyosol, Hyospaz, Hyosyne, Levbid, Levsin, Levsinex,
Losamine, Medispaz, Spacol, Spasdel, Symax
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May Be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Iron
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Anisodus tanguticus*
|
| Side effect reduction/prevention |
None known
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Iron
Absorption of ferrous citrate, an iron compound that is usually well absorbed, is reduced in
individuals taking hyoscyamine;1 therefore, these two substances should not be
taken at the same time.
Interactions with Herbs
Anisodus tanguticus
The herb Anisodus tanguticus contains a chemical that has effects similar to atropine, a compound related to
hyoscyamine.2 Though no human studies have investigated a possible adverse
interaction between hyoscyamine and anisodus, individuals should avoid the combination until
more is known.
Interactions with Foods and Other Compounds
Alcohol
Drinking alcohol interferes with the stomach acid–blocking action of atropine,3 a drug similar to hyoscyamine.
Alcohol may reduce the effectiveness of hyoscyamine for this reason, and should therefore be
avoided by people taking hyoscyamine.
References:1. Orrego-Matte H, Fernandez O, Mena I. Effect of anticholinergic agents
on the intestinal absorption of 59 Fe ferrous citrate. Am J Dig Dis
1971;16:789–95.
2. Qicheng F. Some current study and research approaches relating to the
use of plants in the traditional Chinese medicine. J Ethnopharmacol
1980;2:57–63.
3. Kolbel CB, Singer MV, Mohle T, et al. Action of intravenous ethanol
and atropine on the secretion of gastric acid, pancreatic enzymes and bile acids and the
motility of the upper gastrointestinal tract in nonalcoholic humans. Pancreas
1986;1:211–8.