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Also indexed as: Cytotec

Combination drug: Arthrotec


Misoprostol is a type of drug called a prostaglandin E1 analog that protects the mucosal lining of the stomach and intestines. It is either used alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) to prevent injury to stomach and intestinal tissue caused by these agents.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.


Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

A common side effect of misoprostol is diarrhea, which is aggravated by taking magnesium.1 Consequently, individuals who experience diarrhea while taking misoprostol should avoid magnesium supplementation.

Interactions with Foods and Other Compounds

Taking misoprostol with food may lower the maximum concentration of the drug in the blood and delay (though not decrease) absorption up to ten hours.2 3 However, since ingestion of food with misoprostol may reduce the incidence of diarrhea, it is usually recommended that the drug be taken with a meal.4


1. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2888–91.

2. Karim A, Smith M. Biopharmaceutical profile of diclofenac-misoprostol combination tablet, Arthrotec. Scand J Rheumatol Suppl 1992;96:37–48.

3. Arns PA. Misoprostol. Am J Med Sci 1991;301:133–7.

4. Garris RE, Kirkwood CF. Misoprostol: a prostaglandin E1 analog. Clin Pharm 1989;8:627–44.

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