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Ipriflavone

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Ipriflavone is a synthetic flavonoid (isoflavone) derived from the soy compound daidzein.

Where is it found?

Ipriflavone does occur naturally in food but only in trace amounts. It is available as a nutritional supplement.

Ipriflavone has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings Health Concerns
2Stars

Osteoporosis

3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

As ipriflavone is not an essential nutrient, no deficiency state exists.

How much is usually taken?

The typical supplemental amount of ipriflavone is 200 mg three times daily. Taking 300 mg twice daily has been reported to be just as effective as 200 mg three times per day.1

Are there any side effects or interactions?

In a trial of ipriflavone for osteoporosis, 29 of the 132 women in the ipriflavone group completing the three-year trial developed a clinically significant drop in lymphocytes.2 These cells, which make up approximately 22 to 28% of the white blood cells in the normal adult, are critical components of the immune system and its ability to respond to viral infections. In some of these women, a return to normal levels took almost two years after they had stopped the ipriflavone. Since this finding has been reported in one other smaller clinical trial,3 it suggests that women choosing to take ipriflavone should have their lymphocytes measured regularly by their doctor.

In double-blind studies, the frequency of perceived side effects in ipriflavone-treated people (14.5%) was actually less than that observed in people receiving the placebo (16.1%).4 Side effects were mainly mild stomach upset. Researchers recommend that patients with severe kidney disease take a lower amount of ipriflavone (200 to 400 mg daily).5

Are there any drug interactions?
Certain medicines may interact with ipriflavone. Refer to drug interactions for a list of those medicines.

References:

1. Acerbi D, Poli G, Ventura P. Comparative bioavailability of two oral formulations of ipriflavone in healthy volunteers at steady-state. Evaluation of two different dosage schemes. Eur J Drug Metabol Pharmacokinet 1998,23:172–7.

2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis. JAMA 2001;285:1482–8.

3. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61:23–27.

4. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 199:61:S23–7 [includes review].

5. Rondelli I, Acerbi D, Ventura P. Steady-state pharmacokinetics of ipriflavone and its metabolites in patients with renal failure. Int J Clin Pharm Res 1991;11:183–92.

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